Jan Wehkamp Selected Research

Defensins

1/2021	Human β-Defensin 2 Mutations Are Associated With Asthma and Atopy in Children and Its Application Prevents Atopic Asthma in a Mouse Model.
1/2021	Human β-defensin-2 suppresses key features of asthma in murine models of allergic airways disease.
1/2020	The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus.
1/2020	Human β-Defensin 2 Mediated Immune Modulation as Treatment for Experimental Colitis.
1/2019	Human Paneth cell α-defensin-5 treatment reverses dyslipidemia and improves glucoregulatory capacity in diet-induced obese mice.
1/2018	β-Defensin 1 Is Prominent in the Liver and Induced During Cholestasis by Bilirubin and Bile Acids via Farnesoid X Receptor and Constitutive Androstane Receptor.
11/2015	Crohn's disease-derived monocytes fail to induce Paneth cell defensins.
9/2014	TCF-1-mediated Wnt signaling regulates Paneth cell innate immune defense effectors HD-5 and -6: implications for Crohn's disease.
1/2013	Inflammatory bowel disease: an impaired barrier disease.
1/2013	Gastric antimicrobial peptides fail to eradicate Helicobacter pylori infection due to selective induction and resistance.

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Jan Wehkamp Research Topics

Disease

40	Crohn Disease (Crohn's Disease) 05/2020 - 07/2002
24	Inflammation (Inflammations) 01/2021 - 07/2003
19	Ulcerative Colitis 02/2019 - 07/2002
15	Inflammatory Bowel Diseases (Inflammatory Bowel Disease) 01/2018 - 07/2002
9	Infections 01/2021 - 09/2005
5	Colitis 01/2020 - 07/2002
3	Body Weight (Weight, Body) 01/2020 - 01/2017
3	Fistula 02/2019 - 05/2008
3	Ileitis 10/2017 - 09/2008
3	Ileal Diseases 09/2008 - 01/2005
2	Asthma (Bronchial Asthma) 01/2021 - 01/2021
2	Disease Progression 02/2019 - 10/2017
2	Pathologic Constriction (Stenosis) 09/2017 - 12/2016
2	Gastrointestinal Diseases (Functional Gastrointestinal Disorders) 02/2009 - 09/2005
2	Colonic Diseases 08/2006 - 04/2005
1	Pneumonia (Pneumonitis) 01/2021
1	Respiratory Hypersensitivity 01/2021
1	Virus Diseases (Viral Diseases) 01/2020
1	Dysbiosis 01/2020
1	Proctitis 02/2019
1	Acute Kidney Injury (Acute Renal Failure) 02/2019
1	Intestinal Fistula 02/2019
1	Obesity 01/2019
1	Dyslipidemias (Dyslipidemia) 01/2019
1	Non-alcoholic Fatty Liver Disease 01/2019
1	Cholestasis 01/2018
1	Ileus 01/2018
1	Short Bowel Syndrome 01/2018
1	Colorectal Neoplasms (Colorectal Cancer) 01/2018
1	Weight Gain 01/2017
1	Metabolic Diseases (Metabolic Disease) 01/2017
1	Aspergillosis 10/2015
1	Psoriasis (Pustulosis Palmaris et Plantaris) 10/2015
1	Tinea (Ringworm) 10/2015

Drug/Important Bio-Agent (IBA)

25	DefensinsIBA 01/2021 - 07/2002
10	Antimicrobial PeptidesIBA 01/2019 - 07/2002
9	Peptides (Polypeptides)IBA 01/2020 - 07/2002
9	beta-DefensinsIBA 09/2008 - 07/2002
6	SteroidsIBA 01/2021 - 09/2007
6	Phenobarbital (Luminal)FDA Link 07/2011 - 07/2003
5	alpha-DefensinsIBA 02/2010 - 12/2005
5	Messenger RNA (mRNA)IBA 02/2010 - 07/2002
4	Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA 02/2019 - 01/2008
4	Anti-Bacterial Agents (Antibiotics)IBA 05/2008 - 06/2003
3	CytokinesIBA 01/2021 - 01/2008
3	Pharmaceutical PreparationsIBA 05/2020 - 12/2013
3	LigandsIBA 10/2017 - 01/2009
3	Protease Inhibitors (Protease Inhibitor)IBA 01/2013 - 04/2007
3	ElafinIBA 01/2013 - 04/2007
3	Leukocyte L1 Antigen Complex (Calgranulin)IBA 12/2012 - 02/2009
3	Interleukin-8 (Interleukin 8)IBA 02/2010 - 04/2007
3	CathelicidinsIBA 07/2007 - 06/2006
2	Ustekinumab (CNTO 1275)FDA Link 05/2020 - 07/2019
2	Biological ProductsIBA 07/2019 - 01/2018
2	C-Reactive ProteinIBA 02/2019 - 02/2009
2	Mesalamine (Mesalazine)FDA LinkGeneric 02/2019 - 08/2015
2	Pattern Recognition ReceptorsIBA 01/2018 - 02/2014
2	AntibodiesIBA 01/2018 - 02/2016
2	Monoclonal AntibodiesIBA 01/2018 - 12/2012
2	IntegrinsIBA 01/2018 - 02/2016
2	Transcription Factor 4IBA 07/2011 - 01/2009
2	RNA-Directed DNA Polymerase (Reverse Transcriptase)IBA 06/2006 - 07/2002
1	Interleukin-13IBA 01/2021
1	OvalbuminIBA 01/2021
1	Bronchodilator Agents (Bronchodilators)IBA 01/2021
1	Antimicrobial Cationic PeptidesIBA 01/2021
1	Methacholine Chloride (Methacholine)FDA Link 01/2021
1	Interleukin-9 (Interleukin 9)IBA 01/2021
1	Amylases FDA Link 01/2020
1	Dextrans (Dextran)FDA Link 01/2020
1	Trypsin InhibitorsIBA 01/2020
1	Interleukin-10 (Interleukin 10)IBA 01/2020
1	Chemokine ReceptorsIBA 01/2020
1	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/2020
1	Adrenal Cortex Hormones (Corticosteroids)IBA 02/2019
1	SalicylatesIBA 02/2019
1	Suppositories (Vaginal Suppositories)IBA 02/2019
1	Tacrolimus (Prograf)FDA LinkGeneric 02/2019
1	NLR ProteinsIBA 01/2018
1	Constitutive Androstane ReceptorIBA 01/2018
1	teduglutideIBA 01/2018
1	Interleukin-1 (Interleukin 1)IBA 01/2018
1	Azathioprine (Imuran)FDA LinkGeneric 01/2018
1	Bile Acids and Salts (Bile Acids)IBA 01/2018
1	BilirubinIBA 01/2018
1	Analgesics (Analgesic Drugs)IBA 10/2017
1	CannabinoidsIBA 10/2017
1	Cannabinoid Receptors (Cannabinoid Receptor)IBA 10/2017
1	EndocannabinoidsIBA 10/2017
1	Biomarkers (Surrogate Marker)IBA 04/2017
1	EndotoxinsIBA 01/2017
1	FructoseIBA 01/2017
1	Budesonide (Pulmicort)FDA LinkGeneric 02/2016
1	Reducing AgentsIBA 10/2015
1	Glutathione (Reduced Glutathione)IBA 10/2015
1	ThioredoxinsIBA 10/2015

Therapy/Procedure

14	Therapeutics 01/2021 - 01/2007
1	Oral Administration 01/2021
1	Transplantation 01/2020
1	Remission Induction 04/2017